Breathing dirty air takes a heavy toll on gut bacteria, boosting risk of obesity, diabetes, gastrointestinal disorders and other chronic illnesses, new University of Colorado Boulder research suggests.
“We know from previous research that air pollutants can have a whole host of adverse health effects,” said senior author Tanya Alderete, an assistant professor of integrative physiology, pointing to studies linking smog with Type 2 diabetes, weight gain and inflammatory bowel diseases. “The takeaway from this paper is that some of those effects might be due to changes in the gut.”
While much attention has been paid to respiratory health, Alderete’s previous studies have shown pollution can also impair the body’s ability to regulate blood sugar and influence risk for obesity. Other research has shown visits to emergency rooms for gastrointestinal problems spike on high pollution days, and youth with high exposure to traffic exhaust have greater risk of developing Crohn’s disease.
To investigate just what might be going on inside the gut, Alderete’s team used cutting-edge whole-genome sequencing to analyze fecal samples from 101 young adults in Southern California.
The researchers looked at data from air-monitoring stations near the subjects’ addresses to calculate their previous-year exposure to ozone (which forms when emissions from vehicles are exposed to sunlight), particulate matter (hazardous particles suspended in the air), and nitrous oxide (a toxic byproduct of burning fossil fuel).
Of all the pollutants measured, ozone had the greatest impact on the gut by far, accounting for about 11% of the variation seen between study subjects — more of an impact than gender, ethnicity or even diet. Those with higher exposure to ozone also had less variety of bacteria living in their gut.
“This is important since lower (bacteria) diversity has been linked with obesity and Type 2 diabetes,” noted Alderete.
Subjects with higher exposure to ozone also had a greater abundance of a specific species called Bacteroides caecimuris. That’s important, because some studies have associated high levels of Bacteroides with obesty.
In all, the researchers identified 128 bacterial species influenced by increased ozone exposure. Some may impact the release of insulin, the hormone responsible for ushering sugar into the muscles for energy. Other species can produce metabolites, including fatty acids, which help maintain gut barrier integrity and ward off inflammation.
“Ozone is likely changing the environment of your gut to favor some bacteria over others, and that can have health consequences,” said Alderete. “A lot of work still needs to be done, but this adds to a growing body of literature showing that human exposure to air pollution can have lasting, harmful effects on human health.”
She said she hopes her work will ultimately influence policymakers to consider moving parks, playgrounds and housing developments away from busy roads and high pollution areas, and invest more in meeting or exceeding air quality standards.
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